Advanced Gluten Disorder & Wheat Sensitivity Panel

SAR 399

The Advanced Gluten Disorder & Wheat Sensitivity Panel is a comprehensive laboratory test designed to evaluate immune markers associated with celiac disease and other gluten-related disorders. By combining multiple antibody tests, this panel provides a more detailed assessment than standard celiac screening and may help identify both typical and atypical presentations.

What Is the Advanced Gluten Disorder & Wheat Sensitivity Panel?

This blood test evaluates several immune markers involved in the body’s response to gluten and tissue transglutaminase. It is intended to support the assessment of:
Celiac disease
Early or silent celiac disease
Non-classical presentations of gluten-related disorders
Gluten-associated skin manifestations
Patients with persistent symptoms requiring further evaluation

Used to diagnose:

  • Celiac Disease
  • Early or Silent Celiac Disease
  • Non-Celiac Gluten Sensitivity (NCGS)
  • Gluten-Related Skin Disorders
  • Cases with Unclear Symptoms

What Does the Advanced Wheat and Gluten Sensitivity Test Detect?

The test includes a set of precise markers to increase diagnostic sensitivity:

Tissue Transglutaminase (tTG)

Detects antibodies associated with celiac disease, and is also used to monitor response to a gluten-free diet.

tTG neo-epitope

An advanced marker for early detection of intestinal damage before severe symptoms develop.

mTG neo-epitope

Helps assess the immune response to dietary-processed gluten.

TG3 (Transglutaminase 3)

Associated with skin problems such as chronic itching and celiac-related rash.

PT-Gliadin (Frazer’s Fraction)

Increases diagnostic accuracy in non-traditional cases.

EMA

A highly accurate confirmatory test for celiac disease.

DGP

Important for children and those with IgA deficiency, and helps with early detection.

Total IgA Measurement

Helps interpret results accurately and reduces the likelihood of false negatives.

Features of the Advanced Wheat Sensitivity Test

Comprehensive diagnosis of all gluten disorders
Early detection before obvious intestinal damage occurs
Supports diagnosis of cases without gastrointestinal symptoms
Reduces false negatives
Tests performed in both IgA and IgG formats for increased accuracy
Suitable before starting a gluten-free diet

When Do You Need the Wheat and Gluten Sensitivity Test?

The test is recommended in the following cases:

  • Bloating, diarrhea, chronic constipation
  • Recurrent abdominal pain
  • Unexplained weight loss
  • Anemia of unknown cause
  • Chronic fatigue
  • Persistent rash or itching
  • Family history of celiac disease
  • Persistent symptoms despite normal results in traditional tests

Difference Between Traditional Wheat Sensitivity Test and Advanced Test

The traditional test focuses only on diagnosing celiac disease,
while the Advanced Wheat and Gluten Sensitivity Test evaluates a broader spectrum of gluten disorders, making it a more accurate diagnostic option in unclear or complex cases.

How Is the Test Performed?

  • Simple blood sample
  • No fasting required
  • It is preferable not to stop gluten intake before the test unless medically directed
  • Results appear within a short period depending on the laboratory

Why Is This Test Important?

Early diagnosis of gluten disorders prevents long-term complications such as:

  • Malabsorption
  • Vitamin deficiency
  • Osteoporosis
  • Skin disorders
  • Growth problems in children

Choosing the right test helps establish an accurate and safe dietary treatment plan.


Package Benefits
Comprehensive evaluation of gluten-related immune disorders.
Supports early detection of celiac disease.
Includes multiple complementary immune markers for improved diagnostic accuracy.
Helps assess atypical or non-classical clinical presentations.
Includes Total IgA to improve interpretation of antibody testing.
Suitable for adults and children when clinically indicated.
Who Should Consider This Panel?
Your healthcare provider may recommend this panel if you experience:
Persistent bloating, abdominal pain, diarrhea, or constipation.
Unexplained iron deficiency anemia.
Chronic fatigue.
Unintentional weight loss.
Persistent skin rash or itching suggestive of dermatitis herpetiformis.
A family history of celiac disease.
Ongoing symptoms despite previous negative or inconclusive screening tests.
Important Information Before Testing
A simple blood sample is required.
Fasting is not required.
Do not start or stop a gluten-free diet before testing unless instructed by your healthcare provider, as avoiding gluten before testing may reduce antibody levels and affect diagnostic accuracy.
Important Note: This panel supports the evaluation of gluten-related disorders but does not establish a diagnosis on its own. Test results should always be interpreted by a qualified healthcare professional together with clinical symptoms, medical history, and, when appropriate, additional investigations such as intestinal biopsy.

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